Preparation and in vitro evaluation of donepezil hydrochloride orodispersible tablets

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mixture were subjected for pre post evaluation including FTIR spectroscopy, micromeritic properties, tablet weight variation, hardness, friability, drug content, wetting time, dispersion water absorption ration, disintegration time in vitro release. Results: low SD indicate the content uniform, suggest no interaction between excipients used. DO-ODTs prepared higher concentration shows better release relative properties than crospovidone esculentus. Conclusion: results this work reveals that absorption, dispersion, rapid fast good further conclude can be efficiently successfully formulated by direct method.